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Updated: Jul 11, 2026

Generation of Human Alloantigen-specific T Cells from Peripheral Blood
Published on: November 21, 2014
Naturally occurring B-cell autoreactivity: a critical overview
Stratis Avrameas1, Therese Ternynck, Ioannis A Tsonis
1Department of Pathophysiology, Medical School, University of Athens, 75 M. Asias, 11527 Athens, Greece. avrameasstratis@yahoo.fr
Abstract:
In over one century of research in immunology marked progress in the scientific knowledge and the implications derived from it has been made. At the same time several contradictory and seemingly opposing results have been obtained. The term autoimmunity is still conceived by many as a term directly related to an immunopathological state. However, strong evidence exist that not only the immune system is able to recognize self-constituents, but it appears also that this property is essential for homeostasis. Direct or indirect alterations of such self-recognition properties of the immune system may contribute to pathology. In this review, the most recent advances in the field of naturally occurring B-cell autoreactivity in health as well as in disease are presented and discussed.
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