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Updated: Jul 11, 2026

A High Content Imaging Assay for Identification of Botulinum Neurotoxin Inhibitors
14:10

A High Content Imaging Assay for Identification of Botulinum Neurotoxin Inhibitors

Published on: November 14, 2014

A neuronal cell-based botulinum neurotoxin assay for highly sensitive and specific detection of neutralizing serum

Sabine Pellett1, William H Tepp, Colin M Clancy

  • 1Food Research Institute, Department of Bacteriology, University of Wisconsin, Madison, WI 53706, United States.

FEBS Letters
|September 25, 2007
PubMed

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Botulism01:22

Botulism

Botulism is a life-threatening neuroparalytic condition caused by botulinum neurotoxin, which is produced by the bacterium Clostridium botulinum, a Gram-positive, spore-forming, obligate anaerobe.In adults, the toxin enters the body in different ways: in foodborne botulism, the preformed toxin is absorbed in the intestine. In wound botulism, spores grow in injured tissue and release the toxin into the blood. Infant botulism differs mechanistically from adult forms. In infants, botulism commonly...