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Related Experiment Videos

Hyperpolarized (129)Xe MRI: a viable functional lung imaging modality?

Samuel Patz1, F William Hersman, Iga Muradian

  • 1Center for Pulmonary Functional Imaging, Brigham and Women's Hospital, 221 Longwood Avenue, Boston, MA 02115, USA. patz@bwh.harvard.edu

European Journal of Radiology
|September 25, 2007
PubMed
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Hyperpolarized (129)Xenon (Xe) MRI shows promise for lung imaging, enabling noninvasive measurement of alveolar surface area and pulmonary oxygen levels (pO(2)). Advancements in polarizer technology are improving (129)Xe output and potential clinical applications.

Area of Science:

  • Pulmonary Medicine
  • Medical Imaging
  • Biophysics

Background:

  • Helium-3 (He) is currently preferred for hyperpolarized gas MRI of the lungs due to signal strength and availability.
  • Hyperpolarized (129)Xenon ((129)Xe) is poised to become the preferred agent due to its abundance and decreasing costs.
  • Recent advancements in polarizer technology have significantly increased (129)Xe output.

Purpose of the Study:

  • To describe human protocols and safety for (129)Xe MRI.
  • To present results for measuring pulmonary oxygen partial pressure (pO(2)) using (129)Xe signal decay.
  • To highlight new technological advancements in (129)Xe polarizer design and output.

Main Methods:

  • Utilized advanced polarizer technology to generate hyperpolarized (129)Xe.

Related Experiment Videos

  • Developed and implemented human protocols for (129)Xe MRI.
  • Analyzed (129)Xe signal decay to determine pO(2), accounting for interphase diffusion.

    • Main Results:

    • Demonstrated the capability of (129)Xe MRI to noninvasively measure alveolar surface area.
    • Successfully measured pulmonary oxygen partial pressure (pO(2)) via (129)Xe signal decay.
    • Reported on enhanced polarizer technology with improved output and compact design.

    Conclusions:

    • Hyperpolarized (129)Xe MRI is a viable functional lung imaging modality with potential for measuring alveolar surface area and pO(2).
    • Addressing interphase diffusion is crucial for accurate pO(2) measurements with (129)Xe.
    • Ongoing technological advancements promise further improvements in (129)Xe polarizer performance and clinical utility.