Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Teeth

Teeth

The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin and...

Oral Cavity

Oral Cavity

The oral cavity, or the mouth, is a complex structure in humans that plays a vital role in our day-to-day lives. Its role is not only in chewing and swallowing food; it also plays a role in speech and facial expressions.
Teeth: The teeth are the hardest structures in our bodies. Humans have two sets of teeth throughout their lifetime: deciduous (baby) teeth and permanent teeth. Each tooth consists of several parts: the crown (visible part), the root (embedded in the jaw), enamel (hard outer...

Tooth Anatomy

Tooth Anatomy

The human tooth enables us to eat a variety of foods, speak clearly, and even aid in shaping our faces. Teeth are composed of various elements that work together. Here's a detailed look at the anatomy of a human tooth.
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or grinding food.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Antagonistic coinfection in rock-paper-scissors models during concurrent epidemics.

Bio Systems·2025

Same author

Does Calcium Phosphate Peri-Implant Grafting Improve Osseointegration of Dental Implants? An Experimental In Vivo Study.

Clinical oral implants research·2025

Same author

Health-related quality of life of patients with metastatic melanoma treated with tumor-infiltrating lymphocytes compared with ipilimumab in a randomized phase III trial.

Annals of oncology : official journal of the European Society for Medical Oncology·2025

Same author

Financial toxicity and socioeconomic impact of cancer in Europe.

ESMO open·2025

Same author

Comparative study of individuals born with orofacial clefts in the United States and Brazil.

Journal of neonatal-perinatal medicine·2025

Same author

Women in Dental Clinical and Translational Research.

Advances in dental research·2024

Search research articles

Related Experiment Video

Updated: Jul 11, 2026

Quantification of Orofacial Phenotypes in Xenopus

Quantification of Orofacial Phenotypes in Xenopus

Published on: November 6, 2014

Defining subphenotypes for oral clefts based on dental development.

A Letra¹, R Menezes, J M Granjeiro

¹Department of Oral Biology and Center for Craniofacial and Dental Genetics, School of Dental Medicine, 614 Salk Hall, University of Pittsburgh, 3501 Terrace Street, Pittsburgh, PA 15261, USA.

Journal of Dental Research

|September 25, 2007

Summary

Dental anomalies are more common in individuals with clefts. Analyzing dental development helped identify cleft subphenotypes, revealing agenesis of the lateral incisor on the non-cleft side as a key indicator.

More Related Videos

Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model

Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model

Published on: November 4, 2025

Related Experiment Videos

Last Updated: Jul 11, 2026

Quantification of Orofacial Phenotypes in Xenopus

Quantification of Orofacial Phenotypes in Xenopus

Published on: November 6, 2014

Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model

Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model

Published on: November 4, 2025

Area of Science:

Oral and Maxillofacial Surgery
Genetics
Pediatric Dentistry

Background:

Individuals with cleft lip and/or palate (CLP) exhibit a higher prevalence of dental anomalies compared to the general population.
Understanding dental development patterns in CLP can aid in subphenotyping and identifying potential genetic influences.

Purpose of the Study:

To investigate dental anomalies as a means to subphenotype clefts.
To identify potential genetic contributions to specific cleft subgroups based on dental development.

Main Methods:

Examined 1000 individuals (500 with clefts, 500 without).
Assessed cleft status using clinical features: completeness, laterality, and dental anomalies.
Employed chi-square and Fisher's exact tests for statistical comparison of anomaly frequencies.

Main Results:

Agenesis of the lateral incisor on the non-cleft side was a significant finding.
Observed considerable differences in dental anomaly frequencies between individuals with and without clefts.
Identified variations in anomaly frequencies among different cleft subphenotypes.

Conclusions:

Dental development analysis is a valuable tool for cleft subphenotyping.
Agenesis of the lateral incisor on the non-cleft side may indicate incomplete bilateral cleft lip.
Further research into genetic contributions to identified cleft subgroups is warranted.