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Related Experiment Video

Updated: Jul 11, 2026

Murine Ileocolic Bowel Resection with Primary Anastomosis

Murine Ileocolic Bowel Resection with Primary Anastomosis

Published on: October 29, 2014

Supplementation with high-dose ascorbic acid improves intestinal anastomotic healing.

M H Cevikel¹, P Tuncyurek, F Ceylan

¹Department of Surgery, Adnan Menderes University, Aydin, Turkey.

European Surgical Research. Europaische Chirurgische Forschung. Recherches Chirurgicales Europeennes

|September 25, 2007

Summary

High-dose vitamin C (ascorbic acid) supplementation significantly improved anastomotic healing in rats by increasing collagen and enhancing tissue strength. Further research is needed to confirm clinical benefits.

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Last Updated: Jul 11, 2026

Murine Ileocolic Bowel Resection with Primary Anastomosis

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Transplantation of Adipose Tissue-Derived Stem Cell Sheet to Reduce Leakage After Partial Colectomy in A Rat Model

Transplantation of Adipose Tissue-Derived Stem Cell Sheet to Reduce Leakage After Partial Colectomy in A Rat Model

Published on: August 11, 2018

Area of Science:

Surgical Research
Gastrointestinal Surgery
Nutritional Science

Background:

Ascorbic acid (vitamin C) is vital for tissue healing.
Its role in intestinal anastomosis healing is not fully understood.
This study investigates ascorbic acid's effect on experimental intestinal resection healing.

Purpose of the Study:

To evaluate the impact of ascorbic acid supplementation on anastomotic healing after intestinal resection in rats.
To determine if varying doses of ascorbic acid influence healing parameters.

Main Methods:

Male Wistar albino rats underwent intestinal resection and were divided into three groups: sham, 100 mg/kg ascorbic acid, and 200 mg/kg ascorbic acid.
Ascorbic acid was administered intramuscularly daily.
Anastomotic bursting pressure, hydroxyproline levels, and histological analysis were performed on postoperative day 7.

Main Results:

Higher doses of ascorbic acid significantly increased anastomotic bursting pressure compared to the sham group.
Hydroxyproline levels, a marker of collagen, were significantly elevated in the high-dose ascorbic acid group.
Histopathological scores demonstrated improved tissue healing with ascorbic acid supplementation.

Conclusions:

Supraphysiological doses of ascorbic acid enhance anastomotic healing in experimental intestinal resection.
Vitamin C supplementation positively influences collagen accumulation, inflammatory response, and anastomotic strength.
The clinical applicability of high-dose ascorbic acid for anastomotic healing requires further investigation.