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Treatment of massive cardiac thrombi in a patient with protein C and protein S deficiency

F Ayşenur Paç1, Deniz N Cağdaş

  • 1Yuksek Ihtisas Education and Research Hospital, Section of Pediatric Cardiology, Ankara, Turkey.

Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis
|September 25, 2007
PubMed

Insights

Patients with myocarditis or dilated cardiomyopathy and protein deficiencies experienced intracardiac thrombi. Anticoagulation therapy successfully resolved thrombi without complications, suggesting routine screening for hemostatic disorders.

Area of Science:

  • Cardiology
  • Hematology

Background:

  • Myocarditis and dilated cardiomyopathy involve cardiac chamber dilation and reduced systolic function.
  • Intracardiac thrombi can be a serious complication in these conditions.

Observation:

  • A patient presented with myocarditis/dilated cardiomyopathy, Protein C and S deficiency, and biventricular thrombi.
  • Treatment involved heparin infusion and acetylsalicylic acid.

Findings:

  • Complete resolution of right ventricular thrombus by day 10.
  • Complete resolution of left ventricular thrombi by day 24.
  • No observed complications like hemorrhage or embolism during treatment.

Implications:

  • Suggests evaluating patients with dilated cardiomyopathy or myocarditis for hemostatic disorders.
  • Highlights the potential benefit of anticoagulation in such patients.
  • Supports the need for tailored treatment strategies considering coagulation status.

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