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Updated: Jul 11, 2026
03:37
Intravitreal Injections in the Ovine Eye
Published on: July 5, 2022
Intravitreal clindamycin for toxoplasmic retinochoroiditis
Lucia Sobrin1, Leila I Kump, C Stephen Foster
1Massachusetts Eye Research and Surgery Institute, Cambridge, Massachusetts 02142, USA.
Retina (Philadelphia, Pa.)
|September 25, 2007
Summary
Intravitreal clindamycin injections effectively treated ocular toxoplasmosis in six patients, resolving inflammation and improving vision. This off-label approach offers a new option for managing this sight-threatening retinal infection.
Area of Science:
- Ophthalmology
- Infectious Diseases
- Retinal Surgery
Background:
- Toxoplasmic retinochoroiditis is a significant cause of posterior uveitis.
- Standard treatment often involves oral medications, which can have limitations.
- Alternative treatment strategies are needed for patients intolerant to or progressing on oral therapies.
Observation:
- This study evaluated the off-label use of intravitreal clindamycin for toxoplasmic retinochoroiditis.
- Six consecutive patients received intravitreal clindamycin injections.
- Some patients also underwent pars plana vitrectomy (PPV) concurrently.
Findings:
- Intravitreal clindamycin led to the resolution of inflammation in all six patients.
- Five patients experienced improved visual acuity after treatment.
- One patient developed a retinal detachment postoperatively after combined clindamycin injection and PPV.
Implications:
- Intravitreal clindamycin appears to be an effective treatment for toxoplasmic retinochoroiditis.
- This approach may be beneficial for patients with limited tolerance or response to oral medications.
- Further research is warranted to establish optimal protocols and long-term safety, especially when combined with PPV.
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