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Updated: Jul 11, 2026
13:19
Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer
Published on: November 2, 2013
Prostate cancer prevention: past, present, and future.
Neil Fleshner1, Alexandre R Zlotta
1Division of Urology, University Health Network, and Department of Surgery (Urology), University of Toronto, Toronto, Ontario, Canada. neil.fleshner@utoronto.ca
Cancer
|September 26, 2007
Summary
Prostate cancer prevention strategies are reviewed, including diet and supplements like vitamins D and E, and selenium. Pharmacological interventions and trial results are also discussed, highlighting ongoing research for definitive answers.
Area of Science:
- Oncology
- Preventive Medicine
- Epidemiology
Background:
- Prostate cancer is a leading male malignancy in Western countries.
- Epidemiological data suggest prostate cancer is preventable.
- Prevention offers benefits in reducing mortality and treatment-related morbidity.
Purpose of the Study:
- To review the evidence and scientific data for various prostate cancer prevention strategies.
- To discuss past, present, and future directions in prostate cancer prevention research.
Main Methods:
- Review of scientific literature and clinical trial data.
- Analysis of dietary interventions (fat reduction, soy, green tea, lycopene, vitamins D and E, selenium).
- Evaluation of pharmacological interventions (cyclo-oxygenase inhibitors, antiestrogens, 5-alpha reductase inhibitors).
Main Results:
- Evidence for dietary and pharmacological prevention strategies is presented.
- The Prostate Cancer Prevention Trial results, including finasteride controversy, are summarized.
- Ongoing phase 2 trials and future phase 3 trial outcomes are anticipated.
Conclusions:
- Prostate cancer prevention is a thoroughly investigated field.
- Definitive answers from major clinical trials are expected within 2-7 years.
- Prevention research aims to reduce prostate cancer incidence and mortality.
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