Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Jul 11, 2026

Methodology for Biomimetic Chemical Neuromodulation of Rat Retinas with the Neurotransmitter Glutamate In Vitro

Methodology for Biomimetic Chemical Neuromodulation of Rat Retinas with the Neurotransmitter Glutamate In Vitro

Published on: December 19, 2017

Retinal neurostimulator for a multifocal vision prosthesis.

Yan T Wong¹, Norbert Dommel, Philip Preston

¹Graduate School of Biomedical Engineering, University of New South Wales, Sydney NSW 2052, Australia.

IEEE Transactions on Neural Systems and Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society

|September 27, 2007

Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Improve harms reporting in trials of microelectronic retinal implants.

Therapeutic advances in ophthalmology·2026

Same author

Acoustic Features of Emotional Vocalizations Account for Early Modulations of Event-Related Brain Potentials.

Psychophysiology·2026

Same author

Investigating the Biomechanics to Mimic Blinking using an Electromagnetic Actuator.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2025

Same author

Computational framework and tools for evaluating engineered channelrhodopsin performance in a degenerated retina.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2025

Same author

Prototype Hardware for Closed-loop Stimulation of the Retina.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2025

Same author

Advances in biosensors for diagnosis and monitoring of inflammatory bowel disease: A review.

Bioengineering & translational medicine·2025

A new neurostimulator integrated circuit enables scalable, high-channel-count stimulation for epi-retinal vision prostheses. This technology aims to restore vision for patients with retinal diseases by precisely stimulating electrodes.

Area of Science:

Biomedical Engineering
Neuroscience
Ophthalmology

Background:

Retinal diseases like retinitis pigmentosa and macular degeneration cause blindness.
Current vision prostheses face challenges in achieving high-resolution visual restoration.

Purpose of the Study:

To develop a scalable neurostimulator integrated circuit for epi-retinal vision prostheses.
To enhance the precision and efficacy of visual stimulation in prosthetic devices.

Main Methods:

Designed a scalable application-specific integrated circuit (ASIC) for neurostimulation.
Implemented circuitry for 14-channel stimulation, expandable to 98 channels.
Utilized a hexagonal electrode mosaic to minimize electrical crosstalk and enable localized charge injection.

More Related Videos

Computational Modeling of Retinal Neurons for Visual Prosthesis Research - Fundamental Approaches

Computational Modeling of Retinal Neurons for Visual Prosthesis Research - Fundamental Approaches

Published on: June 21, 2022

Techniques for Processing Eyes Implanted With a Retinal Prosthesis for Localized Histopathological Analysis

Techniques for Processing Eyes Implanted With a Retinal Prosthesis for Localized Histopathological Analysis

Published on: August 2, 2013

Related Experiment Videos

Last Updated: Jul 11, 2026

Methodology for Biomimetic Chemical Neuromodulation of Rat Retinas with the Neurotransmitter Glutamate In Vitro

Methodology for Biomimetic Chemical Neuromodulation of Rat Retinas with the Neurotransmitter Glutamate In Vitro

Published on: December 19, 2017

Computational Modeling of Retinal Neurons for Visual Prosthesis Research - Fundamental Approaches

Computational Modeling of Retinal Neurons for Visual Prosthesis Research - Fundamental Approaches

Published on: June 21, 2022

Techniques for Processing Eyes Implanted With a Retinal Prosthesis for Localized Histopathological Analysis

Techniques for Processing Eyes Implanted With a Retinal Prosthesis for Localized Histopathological Analysis

Published on: August 2, 2013

Main Results:

Developed a 14-channel neurostimulator ASIC with scalable architecture.
Achieved simultaneous stimulation of 14 electrodes.
Demonstrated reduced electrical crosstalk through hexagonal electrode arrangement.

Conclusions:

The developed neurostimulator ASIC offers a scalable solution for advanced vision prostheses.
The hexagonal electrode configuration improves independent charge injection for better visual perception.
This technology holds promise for restoring sight in patients with retinal degenerative diseases.