Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Functionalized microgel swelling: comparing theory and experiment.

Todd Hoare1, Robert Pelton

  • 1Department of Chemical Engineering, McMaster University, Hamilton, Ontario, Canada. hoaretr@mcmaster.ca

The Journal of Physical Chemistry. B
|September 27, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Poly(sulfobetaine-<i>co</i>-oligoethylene Glycol Methyl Ether Methacrylate) Copolymers with Improved Anti-Fouling and Anti-Coagulant Properties.

Biomacromolecules·2026
Same author

Long-Term Hydrophilic, Anti-Clotting, and Anti-Fibrotic Dynamic Covalent Silicone-Based Biomaterials.

Advanced healthcare materials·2026
Same author

Nanovesicle-Based Delivery of Magnesium Chlorophyllin for Photodynamic Inactivation in Agriculture.

Small science·2026
Same author

A Real-Time Antifouling Multivalent Aptamer Platform for Wash-Free Electrochemical Detection of Low-Abundance Biomarkers in Human Plasma.

Angewandte Chemie (International ed. in English)·2026
Same author

Ultrasound-triggered drug delivery: recent developments and opportunities.

Therapeutic delivery·2025
Same author

Antibiotic-Loaded Calcium Crosslinked Alginate Wound Dressings Fabricated via Pressurized Gas eXpanded Liquids Technology in Combination with Supercritical Adsorptive Precipitation for Treating Methicillin-Resistant <i>Staphylococcus</i> Infections.

ACS applied bio materials·2025
Same journal

Predicting Nirmatrelvir Resistance in SARS-CoV-2 M<sup>pro</sup> Mutants with an Integrated Computational Framework.

The journal of physical chemistry. B·2026
Same journal

From Cation Solvation to Anion Coordination: Lewis-Acidic Boranes Enable Halide Salt Electrolytes.

The journal of physical chemistry. B·2026
Same journal

In Vitro-Prepared A30P Alpha-Synuclein Fibrils Adopt the Conserved and Disease-Relevant Greek Key Fold.

The journal of physical chemistry. B·2026
Same journal

Metastructure Analysis of Self-Assembled Nanocubes with Different Equatorial Methyl Groups Based on Molecular Dynamics Simulations.

The journal of physical chemistry. B·2026
Same journal

A Cocoordinated <sup>1</sup>H Internal Reference Quantifies Proton-Exchange Bias in Coordinated-Water Diffusion.

The journal of physical chemistry. B·2026
Same journal

Unveiling Electrolyte-Dependent Coordination Site Dynamics for Redox Mediator Design in Lithium-O<sub>2</sub> Batteries: Exchange vs Rearrangement.

The journal of physical chemistry. B·2026
See all related articles

A new gel swelling model accurately predicts water content in functionalized microgels. It accounts for salt, charge, chain stiffness, and network properties, outperforming simpler models.

Area of Science:

  • Polymer Science
  • Materials Science
  • Physical Chemistry

Background:

  • Microgels exhibit complex swelling behavior influenced by various factors.
  • Existing models like Flory-Huggins often fail to capture these complexities.
  • Understanding microgel swelling is crucial for applications in drug delivery, sensing, and soft robotics.

Purpose of the Study:

  • To develop and apply a comprehensive gel swelling model for -COOH-functionalized poly(N-isopropylacrylamide) microgels.
  • To investigate the influence of salt concentration, charge condensation, chain stiffness, and network heterogeneity on microgel swelling.
  • To correlate model predictions with rheological measurements and polymerization parameters.

Main Methods:

  • Application of a comprehensive gel swelling model incorporating salt effects, charge condensation, chain flexibility, and network structure.

Related Experiment Videos

  • Rheological measurements to determine experimental water fractions of microgels.
  • Correlation of model-predicted cross-linking efficiency with comonomer behavior during polymerization.

    • Main Results:

    • The model successfully orders microgels by water fraction and explains swelling differences based on functionalization and cross-linking.
    • Model predictions align with rheologically measured water content when cross-linking efficiency is adjusted.
    • The model accurately captures microgel swelling responses to varying salt concentrations.

    Conclusions:

    • The developed model provides a robust framework for predicting microgel swelling, surpassing the limitations of the Flory-Huggins model.
    • It effectively accounts for key physical parameters and heterogeneities influencing microgel behavior.
    • The findings offer insights into microgel design and performance based on polymerization characteristics.