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Related Concept Videos

Drug Delivery: Overview01:16

Drug Delivery: Overview

700
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
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Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

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Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
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Drug Delivery: Parenteral Route01:29

Drug Delivery: Parenteral Route

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The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
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Ultrasonography01:17

Ultrasonography

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Ultrasonography is an imaging technique that uses high-frequency sound waves to visualize the body's internal structures. It is a non-invasive and safe procedure that does not involve the use of ionizing radiation, making it widely used in various medical fields. Ultrasonography is used to study heart function, blood flow in the neck or extremities, certain conditions such as gallbladder disease, and fetal growth and development.
During an ultrasonography procedure, a handheld device called...
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Drug Delivery: Enteral Route01:18

Drug Delivery: Enteral Route

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The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
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Related Experiment Video

Updated: Jan 7, 2026

Multi-timescale Microscopy Methods for the Characterization of Fluorescently-labeled Microbubbles for Ultrasound-Triggered Drug Release
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Ultrasound-triggered drug delivery: recent developments and opportunities.

Kayla Baker1, Cameron Macdonald1, Todd Hoare1

  • 1Department of Chemical Engineering, McMaster University, Hamilton, Ontario, Canada.

Therapeutic Delivery
|December 25, 2025
PubMed
Summary

Ultrasound-triggered drug delivery vehicles offer precise, localized treatment by leveraging various ultrasound effects for controlled release. This review highlights designs for targeted therapies and discusses challenges for clinical application.

Keywords:
Ultrasoundburst releaseon-demandpulsatile releasesustained release

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Pharmacology

Background:

  • Ultrasound is a safe, accessible imaging tool with potential for drug delivery.
  • Current drug delivery methods face challenges in precise localization.
  • Ultrasound offers unique physical effects for triggering drug release.

Purpose of the Study:

  • To review emerging drug delivery vehicles activated by ultrasound.
  • To analyze designs enabling controlled drug release kinetics.
  • To discuss clinical translation barriers and future directions.

Main Methods:

  • Literature review of ultrasound-triggered drug delivery systems.
  • Analysis of vehicle designs based on ultrasound effects (cavitation, heating, etc.).
  • Categorization of release profiles: delayed burst, sustained, and pulsatile.

Main Results:

  • Various ultrasound effects can activate drug release from engineered vehicles.
  • Designs allow for precise control over drug release kinetics (delayed, sustained, pulsatile).
  • Synergistic therapeutic benefits of ultrasound combined with drug delivery are observed.

Conclusions:

  • Ultrasound-triggered drug delivery vehicles show promise for localized disease treatment.
  • Scalable and reproducible designs are needed for clinical translation.
  • Overcoming barriers is crucial for real-world patient impact.