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Updated: Aug 10, 2026

Adaptation of Microelectrode Array Technology for the Study of Anesthesia-induced Neurotoxicity in the Intact Piglet Brain
Published on: May 12, 2018
[The use of moradol for optimizing the recovery from neuroleptanesthesia]
Abstract:
The study has been performed right after surgery in 20 patients of the test group (subgroups I and II) and 20 control patients. Surgery for urologic cancer has been performed in all the patients by transabdominal approach using general anesthesia based on neuroleptanesthesia (NLA). It has been shown that in patients with hypoventilation moradol, administered intravenously at a dose of 1 mg, restores adequate respiration and gas exchange. Patients with apnea upon administration of 1 mg moradol recovered respiration in hypoventilation regimen. Repeated injection of 1 mg moradol promoted the recovery of adequate respiration and gas exchange in all the patients. The patients of the test group were extubated 12.4 +/- 0.1 min on an average after the operation. Control patients, who had not been administered moradol, were extubated 20.4 +/- 0.7 min on an average after the operation. It is shown that the use of moradol in patients after NLA leads to a drastic decrease in the incidence and degree of postoperative pain syndrome and postanesthesia chill.
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