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Related Concept Videos

Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
Transient Ischemic Attack l: Introduction01:26

Transient Ischemic Attack l: Introduction

A transient ischemic attack (TIA) is a brief episode of neurological dysfunction caused by a temporary, focal reduction in cerebral blood flow. Although symptoms resemble those of an ischemic stroke, the interruption in perfusion is short-lived and does not cause permanent infarction. TIAs are clinically important because they often serve as early warning events for future stroke.Mechanisms of Transient Cerebral IschemiaTransient cerebral ischemia may arise through several mechanisms. One...
Stroke: Introduction and Types01:29

Stroke: Introduction and Types

A stroke is an acute neurological event caused by the sudden disruption of cerebral blood flow, leading to rapid loss of neuronal function. Neurons depend on continuous oxygen and glucose supply, so even brief interruptions can cause irreversible injury within minutes. Strokes are classified into ischemic and hemorrhagic types.Ischemic StrokeIschemic strokes are most common and occur due to arterial occlusion, depriving brain tissue of oxygen and nutrients. This leads to energy failure, ionic...
Ischemic Heart Disease: Overview01:17

Ischemic Heart Disease: Overview

Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and narrowing...
Hemorrhagic Stroke l: Introduction01:17

Hemorrhagic Stroke l: Introduction

A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...

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The Application Of Permanent Middle Cerebral Artery Ligation in the Mouse
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Ischemic stroke and n-3 fatty acids.

K N Seidelin1, B Jensen, S B Haugaard

  • 1Department of Neurology, Bispebjerg Hospital, Copenhagen, Denmark; the Danish Instite for Fisheries Research, Technical University of Denmark, Lyngby, Denmark.

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
|September 27, 2007
PubMed
Summary

Essential fatty acid levels in adipose tissue differed between patients with cerebral infarction and controls. Lower linoleic and linolenic acid levels were observed in patients, suggesting altered lipid metabolism, not a direct dietary link.

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Area of Science:

  • Biochemistry
  • Neurology
  • Metabolomics

Background:

  • Subcutaneous adipose tissue fatty acid composition may reflect systemic lipid metabolism.
  • Cerebral infarction (stroke) is a leading cause of disability and mortality.
  • Dietary fatty acids are implicated in cardiovascular health, but their role in cerebral infarction requires further elucidation.

Purpose of the Study:

  • To investigate the correlation between subcutaneous adipose tissue fatty acid profiles and the presence of cerebral infarction.
  • To compare the levels of specific fatty acids, including essential fatty acids and marine n-3 fatty acids, between patients with cerebral infarction and healthy controls.

Main Methods:

  • Adipose tissue microbiopsies were obtained from 10 patients with computed tomography (CT)-verified cerebral infarction and 10 matched controls.
  • Fatty acid content was analyzed using gas-liquid chromatographic analysis.
  • Statistical comparisons were performed to identify significant differences in fatty acid levels.

Main Results:

  • No significant differences were found in marine n-3 fatty acid levels between the groups.
  • Patients with cerebral infarction exhibited significantly lower levels of essential fatty acids, specifically linoleic acid and linolenic acid (P<.05).
  • Elevated levels of palmitoleic acid were observed in patients with cerebral infarction (P<.005), suggesting increased de novo lipid synthesis.

Conclusions:

  • Significant differences in essential fatty acid levels exist in adipose tissue of patients with cerebral infarction.
  • The observed alterations may indicate modified lipid synthesis rather than a direct dietary deficiency.
  • The study does not support a causal relationship between essential fatty acids or dietary patterns like fish consumption and cerebral infarction, nor an association with ischemic stroke.