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Updated: Jul 11, 2026
09:42
A Fibrin-Enriched and tPA-Sensitive Photothrombotic Stroke Model
Published on: June 4, 2021
Benign angioedema after thrombolysis for acute stroke
N I Papamitsakis1, J Kuyl, H L Lutsep
1Oregon Stroke Center, Oregon Health Sciences University, Portland, Oregon, USA.
Summary
Acute angioedema is a rare complication following recombinant tissue plasminogen activator (t-PA) treatment for acute ischemic stroke. Physicians should monitor patients for this potential adverse event.
Area of Science:
- Neurology
- Emergency Medicine
- Pharmacology
Background:
- Acute ischemic stroke is a time-sensitive medical emergency.
- Recombinant tissue plasminogen activator (t-PA) is a critical thrombolytic therapy for acute ischemic stroke.
- Adverse events associated with t-PA require careful monitoring and management.
Purpose of the Study:
- To report a case of acute angioedema following t-PA administration.
- To highlight a potential complication of t-PA therapy for ischemic stroke.
- To increase physician awareness of t-PA-induced angioedema.
Main Methods:
- A case presentation of a patient treated with t-PA for acute ischemic stroke.
- Review of existing literature on t-PA-associated angioedema.
- Adherence to the National Institute of Neurological Disorders and Stroke (NINDS) protocol.
Main Results:
- The patient developed acute angioedema of the lower lip after t-PA administration.
- The angioedema resolved spontaneously within 2 hours.
- Literature review identified five previous cases requiring airway management post-t-PA.
Conclusions:
- Acute angioedema is a potential, albeit rare, complication of t-PA for ischemic stroke.
- Early recognition and awareness are crucial for managing t-PA-related angioedema.
- While outcomes can be excellent, vigilance is necessary for patient safety.
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