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Updated: Jul 11, 2026
07:34
Establishment of a Modified Ferric Chloride-Induced Superior Sagittal Sinus Thrombosis
Published on: December 30, 2025
Superior sagittal sinus thrombosis secondary to hyperthyroidism.
1Department of Neurology, State University of New York at Buffalo, Buffalo, NY, USA.
Summary
Hyperthyroidism may cause superior sagittal sinus thrombosis (SSST), a dangerous blood clot in the brain. Treating thyroid dysfunction led to recovery, suggesting hyperthyroidism is a risk factor for SSST.
Area of Science:
- Neurology
- Endocrinology
- Hematology
Background:
- Superior sagittal sinus thrombosis (SSST) is linked to hypercoagulable states.
- Hyperthyroidism is known to cause coagulation disturbances, but its direct role in cerebral venous thrombosis remains unclear.
Purpose of the Study:
- To investigate the potential association between hyperthyroidism and SSST.
- To determine if hyperthyroidism is an independent risk factor for SSST.
Main Methods:
- Case report of a 39-year-old male patient presenting with symptoms of increased intracranial pressure, seizures, and rapid atrial fibrillation.
- Neuroimaging confirmed SSST.
- Laboratory tests indicated hyperthyroidism; other hypercoagulable causes were ruled out.
- Patient received prompt treatment for hyperthyroidism.
Main Results:
- The patient's neuroimaging revealed SSST.
- Laboratory findings were consistent with hyperthyroidism.
- Following treatment for hyperthyroidism, the patient experienced sinus recanalization and complete neurological recovery.
Conclusions:
- Hyperthyroidism may be an independent risk factor for SSST, potentially due to its effects on factor VIII activity.
- Clinicians should consider SSST in hyperthyroid patients with neurological symptoms.
- Thyroid dysfunction should be evaluated in patients with unexplained SSST.
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