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Related Experiment Video

Updated: Jul 11, 2026

Multiple-mouse Neuroanatomical Magnetic Resonance Imaging
09:08

Multiple-mouse Neuroanatomical Magnetic Resonance Imaging

Published on: February 27, 2011

For how long is brain tissue salvageable? Imaging-based evidence.

J C Baron1, M E Moseley

  • 1INSERM U 320, Centre Cyceron, Caen Cedex, France.

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
|September 27, 2007
PubMed
Summary

Brain imaging shows that potentially salvageable brain tissue after ischemic stroke can exist for up to 16 hours with positron-emission tomography (PET) scanning and up to 24 hours with magnetic resonance imaging (MRI). These techniques help identify penumbra tissue that may be saved.

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Area of Science:

  • Neurology
  • Medical Imaging
  • Stroke Research

Background:

  • The penumbra, brain tissue surrounding an ischemic stroke infarct, is viable but dysfunctional shortly after stroke onset.
  • Neurons in the penumbra are at risk of death as time progresses.
  • Accurate assessment of penumbra viability is crucial for timely therapeutic intervention.

Purpose of the Study:

  • To evaluate the time window for salvageable brain tissue in the penumbra following ischemic stroke.
  • To compare the capabilities of 15O-positron-emission tomography (PET) and advanced magnetic resonance imaging (MRI) techniques in identifying penumbra.

Main Methods:

  • Utilized 15O-positron-emission tomography (PET) scanning to assess tissue perfusion, oxygen consumption, and oxygen extraction fraction in the penumbra.

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Last Updated: Jul 11, 2026

Multiple-mouse Neuroanatomical Magnetic Resonance Imaging
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Published on: February 27, 2011

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  • Employed advanced magnetic resonance imaging (MRI) techniques, specifically diffusion-weighted imaging (DWI) and perfusion-weighted imaging (PWI), to identify salvageable tissue.
  • Applied rigorous criteria to analyze imaging data and determine the extent and duration of the penumbra.

    • Main Results:

    • PET scanning revealed that a viable penumbra, potentially salvageable, can persist for at least 7 to 16 hours post-stroke in some patients.
    • MRI, particularly using a PWI-DWI mismatch signature, identified potentially salvageable penumbral tissue up to 24 hours after stroke onset.
    • Individual patient responses varied, with some showing rapid infarct expansion while others maintained a significant penumbra for extended periods.

    Conclusions:

    • Both PET and advanced MRI techniques are valuable tools for identifying salvageable penumbral tissue after ischemic stroke.
    • The time window for intervention may be longer than previously assumed, especially with MRI, highlighting the importance of advanced neuroimaging.
    • These findings have significant implications for optimizing treatment strategies and improving outcomes for stroke patients.