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Updated: Jul 11, 2026
Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas
Published on: February 28, 2019
Primary sinonasal undifferentiated carcinoma presenting with bilateral retrobulbar optic neuropathy
Madhura A Tamhankar1, Nicholas J Volpe, Laurie A Loevner
1Division of Neuro-ophthalmology, Scheie Eye Institute, Hospital of the University of Pennsylvania, University of Pennsylvania School of Medicine, 51 North 39th Street, Philadelphia, PA 19104, USA.
Abstract:
A 43-year-old man presented with acute bilateral visual loss. Ophthalmologic examination revealed no light perception in the right eye and a visual acuity of 20/50 in the left eye with a right afferent pupillary defect. Ophthalmoscopic examination was normal. Brain MRI showed an intracranial but extra-axial mass in the floor of the anterior cranial fossa extending along the olfactory groove and into the sinonasal vault. Endoscopic biopsy showed a high-grade neoplasm consistent with sinonasal undifferentiated carcinoma. This case report highlights an unusual clinical presentation for this rare and aggressive neoplasm.
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