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Updated: Jul 11, 2026
06:27
Accelerated Type 1 Diabetes Induction in Mice by Adoptive Transfer of Diabetogenic CD4+ T Cells
Published on: May 6, 2013
[Environmental causes of type 1 diabetes]
Kjersti Skjold Rønningen1, Lars Chr Stene, Trond Rasmussen
1Divisjon for epidemiologi, Nasjonalt folkehelseinstitutt, Postboks 4404 Nydalen, 0403 Oslo. kjersti.skjold.ronningen@fhi.no
Summary
Norway
Area of Science:
- Pediatrics
- Endocrinology
- Genetics
Context:
- Type 1 diabetes incidence is rising in Norway.
- Environmental and genetic factors influence type 1 diabetes.
- No specific environmental risk factors for type 1 diabetes have been identified.
Purpose:
- To identify environmental triggers of type 1 diabetes in high-risk children.
- To follow 2,100 newborns with a specific gene combination for 15 years.
- To detect early signs of type 1 diabetes through autoantibodies.
Summary:
- The MIDIA study recruits 100,000 newborns in Norway.
- 2,100 children with a specific gene combination (2.1% prevalence) have a 6-10% risk for type 1 diabetes.
- Data collection includes stool, blood samples, and questionnaires to find diabetes causes.
Impact:
- Aims to identify preventable environmental risk factors for type 1 diabetes.
- Will provide insights into the pathogenesis of type 1 diabetes.
- Informs Norwegian doctors about the study and its ethical considerations.
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