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Updated: Jul 11, 2026

Multicolor Fluorescence Detection for Droplet Microfluidics Using Optical Fibers

Multicolor Fluorescence Detection for Droplet Microfluidics Using Optical Fibers

Published on: May 5, 2016

Microfluidic flow rate detection based on integrated optical fiber cantilever.

Victor Lien¹, Frank Vollmer

¹Rowland Institute, Harvard University, 100 Edwin H. Land Blvd, Cambridge, MA 02142, USA. lien@rowland.harvard.edu

|September 27, 2007

Summary

We developed a microfluidic flow sensor with an ultra-wide dynamic range for high-throughput applications. This fiber-optic sensor accurately measures flow rates from 0 to 1500 µL/min in water.

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Area of Science:

Microfluidics
Optical Sensing
Biotechnology

Background:

High-throughput analysis is crucial for applications like flow cytometry and particle analysis.
Existing flow sensors often lack the dynamic range required for diverse microfluidic applications.
Precise flow rate measurement is essential for controlling microfluidic devices.

Purpose of the Study:

To demonstrate an integrated microfluidic flow sensor with an ultra-wide dynamic range.
To enable high-throughput applications using microfluidic technology.
To provide a tunable and robust flow sensing solution.

Main Methods:

Fabrication of an integrated microfluidic chip with preformed channels for sensor alignment.
Utilizing a fiber-tip cantilever to transduce flow rates into optical signals.
Employing a one-step chemical etch process to adjust the sensor's dynamic range.

Main Results:

Demonstrated an ultra-wide dynamic range of 0 to 1500 µL/min for operation in water.
Achieved precise fiber-optic sensor alignment guided by microfluidic channels.
Showcased the tunability of the dynamic range via a simple chemical etch.

Conclusions:

The developed microfluidic flow sensor offers an ultra-wide dynamic range suitable for high-throughput applications.
The integrated design and tunable nature of the sensor enhance its applicability in flow cytometry and particle analysis.
The sensor provides a cost-effective and efficient solution for microfluidic flow monitoring.