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Cardiopulmonary Bypass in a Mouse Model: A Novel Approach
08:08

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Published on: September 22, 2017

Fluid overload during cardiopulmonary bypass is effectively reduced by a continuous infusion of hypertonic

Venny L Kvalheim1, Stein E Rynning, Marit Farstad

  • 1Department for Heart Disease, University of Bergen, Haukeland University Hospital, Bergen, Norway.

Scandinavian Cardiovascular Journal : SCJ
|September 27, 2007
PubMed

Insights

Hypertonic saline/dextran (HSD) infusion significantly reduced fluid overload and extravasation during cardiopulmonary bypass (CPB). This intervention maintained stable intracranial pressure (ICP) without adverse effects in animal models.

Area of Science:

  • Cardiovascular Surgery
  • Fluid Physiology
  • Critical Care Medicine

Background:

  • Cardiopulmonary bypass (CPB) is frequently associated with significant fluid overload.
  • Managing fluid balance during CPB is crucial for patient outcomes.

Purpose of the Study:

  • To investigate the impact of continuous hypertonic saline/dextran (HSD) infusion on fluid shifts during CPB.
  • To assess the effect of HSD on fluid extravasation, tissue water content, and intracranial pressure.

Main Methods:

  • Fourteen animals were randomized into control (CT) and HSD groups.
  • HSD (1 ml/kg/h) replaced a portion of maintenance fluid during CPB.
  • Measurements included fluid balance, plasma volume, total tissue water (TTW), and intracranial pressure (ICP).

Main Results:

  • The HSD group required 60% less fluid during CPB compared to the CT group.
  • Fluid extravasation rates (FER) were significantly lower in the HSD group (0.38 ml/kg/min vs. 0.74 ml/kg/min).
  • TTW was reduced in cardiac and visceral organs; ICP remained stable in the HSD group, unlike the CT group.

Conclusions:

  • Continuous HSD infusion effectively reduces fluid extravasation and overall fluid gain during CPB.
  • HSD administration leads to decreased tissue water content and maintains stable intracranial pressure.
  • No adverse effects were observed with HSD use during CPB in this study.
Abstract

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