Detection and visualization of surface-pockets to enable phenotyping studies
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Updated: Jul 11, 2026

In-vivo Detection of Protein-protein Interactions on Micro-patterned Surfaces
Published on: March 19, 2010
Kishore Mosaliganti1, Firdaus Janoos, Richard Sharp
1Department of Computer Science and Engineering, The Ohio State University, Columbus, OH 43210, USA. mosaligk@cse.ohio-state.edu
Abstract:
In this paper, we propose a technique for detecting pockets on a surface-of-interest. A sequence of propagating fronts converging to the target surface is used as the basis for inspection. We compute a correspondence function between the initial and the target surface. This leads to a natural definition of the local feature size measured as the evolution distance between mapped points. Surface pockets are then extracted as salient clusters embedded in the feature space. The level-set initialization also determines the scale-space of the extracted pockets. Results are presented on a case-study in which the focus is to chronicle the phenotyping differences in genetically modified mouse placenta. Our results are validated based on manually verified ground-truth.
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