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Mannose binding lectin levels in spondyloarthropathies
Sibel Zehra Aydin1, Pamir Atagunduz, Nevsun Inanc
1Department of Rheumatology, Marmara University Faculty of Medicine, Istanbul, Turkey. drsibelaydin@gmail.com
The Journal of Rheumatology
|September 28, 2007
Summary
Mannose-binding lectin (MBL) deficiency did not differ between ankylosing spondylitis (AS) patients and controls. However, MBL deficiency showed a trend towards more severe spinal radiographic progression in AS patients.
Area of Science:
- Immunology
- Rheumatology
- Genetics
Background:
- Mannose-binding lectin (MBL) is a key component of the innate immune system, and MBL deficiency increases infection susceptibility.
- Gastrointestinal and genitourinary infections are implicated as potential triggers for spondyloarthropathies (SpA).
Purpose of the Study:
- To investigate the prevalence of MBL deficiency in ankylosing spondylitis (AS) and undifferentiated SpA (uSpA).
- To explore the association between MBL deficiency and disease severity in AS.
Main Methods:
- Studied 107 AS patients, 43 uSpA patients, and 74 healthy controls.
- Measured MBL levels using ELISA kits.
- Assessed disease activity, radiological scores, and demographic data.
Main Results:
- No significant differences in median MBL levels or MBL deficiency prevalence were found between AS, uSpA, and control groups.
- MBL levels did not correlate with Bath AS Radiological Index scores.
- AS patients with MBL deficiency exhibited a trend towards higher radiographic damage (mSASSS), approximately three times greater, though not statistically significant.
Conclusions:
- MBL deficiency did not significantly impact disease activity or clinical features in AS patients.
- A tendency towards more severe radiographic spinal progression, as measured by mSASSS, was observed in AS patients with MBL deficiency.
