Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

G-protein Coupled Receptors01:21

G-protein Coupled Receptors

G-protein coupled receptors are ligand binding receptors that indirectly affect changes in the cell. The actual receptor is a single polypeptide that transverses the cell membrane seven times creating intracellular and extracellular loops. The extracellular loops create a ligand specific pocket which binds to neurotransmitters or hormones. The intracellular loops holds onto the G-protein.
G-protein Coupled Receptors01:21

G-protein Coupled Receptors

G-protein coupled receptors are ligand binding receptors that indirectly affect changes in the cell. The actual receptor is a single polypeptide that transverses the cell membrane seven times creating intracellular and extracellular loops. The extracellular loops create a ligand specific pocket which binds to neurotransmitters or hormones. The intracellular loops holds onto the G-protein.
Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists01:23

Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists

Serotonin, a crucial neurotransmitter synthesized by enterochromaffin cells, plays a cardinal role in regulating gastrointestinal (GI) motility. With over 90% of the body's total serotonin in the GI tract, its influence on digestive processes is profound. Serotonin is swiftly released upon various stimuli, such as food boluses or certain drugs, triggering intrinsic sensory neurons in the myenteric plexus and extrinsic vagal and spinal sensory neurons. This leads to the activation of the...
Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists01:27

Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists

5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...
Drug-Receptor Interaction: Agonist01:25

Drug-Receptor Interaction: Agonist

Agonists are drugs that interact with specific receptors in the body to produce a biological response. When an agonist binds to a receptor, it activates or enhances the receptor's function, leading to physiological effects. The interaction between agonist drugs and receptors is crucial for their therapeutic action in various medical treatments.
Agonists can bind to receptors in different ways. Some agonists bind directly to the receptor's active site, mimicking the endogenous ligand's action.
Antidepressant Drugs: MAOIs and Other Agents01:23

Antidepressant Drugs: MAOIs and Other Agents

Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Nitrilase mediated mild hydrolysis of a carbon-14 nitrile for the radiosynthesis of 4-(7-hydroxycarbamoyl-[1-<sup>14</sup> C-heptanoyl]-oxy)-benzoic acid methyl ester, [<sup>14</sup> C]-SHP-141: A novel class I/II histone deacetylase (HDAC) inhibitor.

Journal of labelled compounds & radiopharmaceuticals·2023
Same author

Synthesis of carbon-14-labelled peptides.

Journal of labelled compounds & radiopharmaceuticals·2019
Same author

Preface.

Current radiopharmaceuticals·2019
Same author

Preface.

Current radiopharmaceuticals·2018
Same author

Editorial Review 2017.

Current radiopharmaceuticals·2017
Same author

Targeted Therapy Towards Cancer-A Perspective.

Anti-cancer agents in medicinal chemistry·2016

Related Experiment Video

Updated: Jul 11, 2026

Rapid In Situ Hybridization using Oligonucleotide Probes on Paraformaldehyde-prefixed Brain of Rats with Serotonin Syndrome
08:49

Rapid In Situ Hybridization using Oligonucleotide Probes on Paraformaldehyde-prefixed Brain of Rats with Serotonin Syndrome

Published on: September 23, 2015

5-hydroxytryptamine (5-HT) receptor ligands.

Sean L Kitson1

  • 1GE Healthcare Limited, Amersham Place, Little Chalfont, Buckinghamshire, HP7 9NA, UK. sean.kitson@ge.com

Current Pharmaceutical Design
|September 28, 2007
PubMed
Summary

Serotonin (5-HT) receptors, crucial for brain function, are implicated in numerous neuropsychiatric disorders. Targeting these receptors with drugs offers potential therapeutic strategies for conditions like anxiety and depression.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Molecular Biology

Background:

  • Serotonin (5-HT) receptors are integral components of G protein-coupled and ligand-gated ion channel superfamilies.
  • These receptors mediate diverse physiological actions through cell surface binding, categorized into seven families (5-HT1 to 5-HT7) based on structure and function.
  • Subtypes within 5-HT families exhibit varied operational profiles despite shared structural and mechanistic properties.

Purpose of the Study:

  • To elucidate the critical roles of serotonin (5-HT) receptors in various neuropsychiatric and physiological conditions.
  • To highlight the therapeutic potential of targeting 5-HT receptors for disease treatment.
  • To review the development of selective and non-selective 5-HT receptor ligands (drugs).

Main Methods:

More Related Videos

HSV-Mediated Transgene Expression of Chimeric Constructs to Study Behavioral Function of GPCR Heteromers in Mice
07:30

HSV-Mediated Transgene Expression of Chimeric Constructs to Study Behavioral Function of GPCR Heteromers in Mice

Published on: July 9, 2016

Related Experiment Videos

Last Updated: Jul 11, 2026

Rapid In Situ Hybridization using Oligonucleotide Probes on Paraformaldehyde-prefixed Brain of Rats with Serotonin Syndrome
08:49

Rapid In Situ Hybridization using Oligonucleotide Probes on Paraformaldehyde-prefixed Brain of Rats with Serotonin Syndrome

Published on: September 23, 2015

HSV-Mediated Transgene Expression of Chimeric Constructs to Study Behavioral Function of GPCR Heteromers in Mice
07:30

HSV-Mediated Transgene Expression of Chimeric Constructs to Study Behavioral Function of GPCR Heteromers in Mice

Published on: July 9, 2016

  • Review of existing scientific literature on serotonin receptor structure, function, and pharmacology.
  • Analysis of evidence linking 5-HT receptor dysfunction to neuropsychiatric disorders.
  • Examination of drug development strategies targeting 5-HT receptors.

Main Results:

  • Strong evidence supports the involvement of 5-HT receptors in anxiety, depression, schizophrenia, migraine, and drug addiction.
  • 5-HT receptors are also implicated in obesity, aggression, sexual behavior, and cardiovascular disorders.
  • Development of various selective and non-selective 5-HT receptor agonists and antagonists has been achieved.

Conclusions:

  • Serotonin (5-HT) receptors are key players in a wide range of neuropsychiatric and physiological processes.
  • Targeting specific 5-HT receptor subtypes presents a promising avenue for therapeutic intervention in numerous diseases.
  • Pharmacological modulation of 5-HT receptors is a significant focus in drug development for complex health conditions.