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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells
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Targeted Therapy Towards Cancer-A Perspective.

Sean L Kitson1, Vincenzo Cuccurullo2, Andrea Ciarmiello3

  • 1Department of Biocatalysis and Isotope Chemistry, Almac, 20 Seagoe Industrial Estate, Craigavon, BT63 5QD, United Kingdom.

Anti-Cancer Agents in Medicinal Chemistry
|September 28, 2016
PubMed
Summary
This summary is machine-generated.

Radionuclide antibody conjugates (RACs) and antibody-drug conjugates (ADCs) offer targeted cancer therapy. These biotherapeutics deliver cytotoxic payloads directly to cancer cells, enabling personalized treatment approaches for various cancers.

Keywords:
Radiometalantibody-drug conjugates (ADCs)biovectorscancerradionuclide antibody conjugatestargeted alpha therapy

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Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
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Area of Science:

  • Oncology
  • Radiochemistry
  • Immunotherapy

Background:

  • Radionuclide antibody conjugates (RACs) and antibody-drug conjugates (ADCs) are emerging biotherapeutics for cancer treatment.
  • These conjugates act as targeted delivery systems for cytotoxic payloads.
  • Advancements in technology platforms are enabling personalized cancer treatment programs.

Purpose of the Study:

  • To provide an insight into targeted therapies using RACs and ADCs.
  • To highlight the potential of these conjugates in treating various cancer types.
  • To discuss the role of new technologies in facilitating personalized cancer treatment.

Main Methods:

  • Conjugation of radionuclides and cytotoxic drugs to biovectors (antibodies).
  • Targeting cancer cell surface antigens for precise drug delivery.
  • Utilizing alpha and/or beta particle emission for cell death induction.

Main Results:

  • RACs and ADCs can effectively target and destroy cancer cells.
  • The technology facilitates a personalized approach to cancer patient treatment.
  • Delivery of cytotoxic payloads directly to the tumor site initiates cell death.

Conclusions:

  • Targeted therapies like RACs and ADCs represent a promising strategy in oncology.
  • Personalized treatment programs are enhanced by advancements in imaging, drug design, and radiochemistry.
  • These biotherapeutic missiles offer a precise method for cancer cell destruction.