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Updated: Jul 11, 2026
In Vivo Multimodal Imaging and Analysis of Mouse Laser-Induced Choroidal Neovascularization Model
Published on: January 21, 2018
[Retinal thickness of laser radiating zone after photodynamic therapy]
Xiao-Bing Yu1, Hong Dai, Ying-Yi Lu
1Department of Ophthalmology, Beijing Hospital, Beijing 100730, China. yuxiaobing@sina.com
Objective:
To observe changes of retinal thickness after photodynamic therapy (PDT) for patients with subfoveal choroidal neovascularization (CNV), and evaluate the effect of retinal edema after PDT.
Methods:
PDT was performed on 27 eyes of 25 patients with subfoveal CNV, the spot diameter of laser beam was 1.8 - 4.3 mm (average 2.9 mm), OCT was used to evaluate the changes of retinal thickness including the retinal thickness of macular fovea and 3 mm laser radiating zone 24 hour 1 week, 1 month, 3 month after PDT. Retinal thickness was compared before PDT and 24 h, 1 week, 1 month, 3 month after PDT respectively.
Results:
Retinal thickness of fovea before PDT and 24 h, 1 week, 1 month, 3 month was (278.07 +/- 85.31), (324.52 +/- 96.08), (242.74 +/- 67.40), (234.26 +/- 51.04) microm and (239.73 +/- 52.81) microm respectively, the average retinal thickness of 3 mm laser radiating zone was (266.71 +/- 60.82), (309.25 +/- 82.69), (257.48 +/- 52.48), (245.44 +/- 47.54) microm and (244.88 +/- 44.22) microm respectively. There was statistical significance before PDT compared with 24 h, 1 month, 3 month after PDT (P < 0.01).
Conclusions:
The result of our study indicate that retinal thickness of laser radiating zone increases apparently 24 h after PDT and regresses during the first week. It suggest that retinal edema after PDT may due to the leakage from the CNV, increased permeability in choroid and retina of laser radiating zone, and transient dysfunction of retinal pigment epithelial cells.
