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Related Concept Videos

Chronic Pancreatitis II: Collaborative Care01:29

Chronic Pancreatitis II: Collaborative Care

The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
Chronic Pancreatitis I: Introduction01:25

Chronic Pancreatitis I: Introduction

Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80% of...
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Chronic Pancreatitis II: Pathophysiology01:21

Chronic Pancreatitis II: Pathophysiology

Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...
Acute Pancreatitis II: Clinical Manifestations and Management01:30

Acute Pancreatitis II: Clinical Manifestations and Management

Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
Acute Pancreatitis I: Introduction01:25

Acute Pancreatitis I: Introduction

Acute pancreatitis is the sudden inflammation of the pancreas caused by the early activation of digestive enzymes, leading to the autodigestion of pancreatic tissue. This results in local inflammation and, in severe cases, systemic complications.EtiologyUnderstanding the underlying causes is crucial, as identifying the etiology guides treatment and anticipates complications. Acute pancreatitis can be triggered by various factors, typically grouped into the following clinical categories.Biliary...

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Updated: Jul 11, 2026

Robotic-assisted Lateral Pancreaticojejunostomy for Chronic Pancreatitis
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Robotic-assisted Lateral Pancreaticojejunostomy for Chronic Pancreatitis

Published on: September 5, 2025

Current treatment options for chronic pancreatitis.

Ayman M Abdel Aziz, Glen A Lehman

    Current Treatment Options in Gastroenterology
    |September 28, 2007
    PubMed
    Summary

    Chronic pancreatitis (CP) involves irreversible pancreatic damage, often caused by alcohol. Treatment focuses on managing maldigestion, pain, and diabetes through various medical, endoscopic, and surgical interventions.

    Area of Science:

    • Gastroenterology and Hepatology
    • Surgical Research
    • Endocrinology

    Background:

    • Chronic pancreatitis (CP) is a progressive, irreversible pancreatic injury.
    • Alcohol abuse is the primary cause of CP in Western countries.
    • Understanding CP pathophysiology is key to improving treatment success.

    Purpose of the Study:

    • To review current therapeutic strategies for chronic pancreatitis.
    • To highlight challenges and emerging options for managing CP complications.

    Main Methods:

    • Review of existing literature on CP management.
    • Analysis of therapeutic approaches for maldigestion, pain, and diabetes.
    • Evaluation of endoscopic, surgical, and interventional pain relief techniques.

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    An Obstructive Chronic Pancreatitis Model Established Through Electrocoagulation
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    Robotic-assisted Lateral Pancreaticojejunostomy for Chronic Pancreatitis
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    Published on: September 5, 2025

    An Obstructive Chronic Pancreatitis Model Established Through Electrocoagulation
    06:28

    An Obstructive Chronic Pancreatitis Model Established Through Electrocoagulation

    Published on: October 31, 2025

    Main Results:

    • Pancreatic enzyme therapy requires careful dosage and timing for malabsorption.
    • Acid suppression with non-enteric-coated enzymes offers limited pain relief.
    • Extracorporeal shock wave lithotripsy (ESWL) and endoscopic therapies show promise for stone management and pain relief.
    • Celiac plexus block and radiation therapy are options for refractory pain, requiring further study.
    • Total pancreatectomy with autologous islet cell transplantation is a last resort for intractable pain.

    Conclusions:

    • Effective CP management requires a multi-faceted approach targeting specific symptoms.
    • Endoscopic and interventional procedures offer significant potential for pain and stone management.
    • Novel and established therapies continue to evolve for refractory CP cases.