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Updated: Jul 11, 2026
07:24
Repression of Multiple Myeloma Cell Growth In Vivo by Single-wall Carbon Nanotube (SWCNT)-delivered MALAT1 Antisense Oligos
Published on: December 13, 2018
Novel therapies in myeloma
Patrick J Hayden1, Constantine S Mitsiades, Kenneth C Anderson
1Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA.
Current Opinion in Hematology
|September 28, 2007
Summary
Novel therapies like immunomodulatory drugs and proteasome inhibitors are now standard for treating multiple myeloma. Research focuses on optimizing their use and exploring new agents for improved patient outcomes.
Area of Science:
- Hematology
- Oncology
- Pharmacology
Background:
- Multiple myeloma treatment has advanced with new drug approvals.
- Understanding the efficacy and optimal use of these novel agents is crucial.
Purpose of the Study:
- To summarize clinical trial data for recently approved myeloma therapies.
- To discuss the current evidence supporting their use in clinical practice.
- To review promising agents in early-phase trials.
Main Methods:
- Review of clinical trials for novel myeloma therapies.
- Analysis of current evidence for drug efficacy and safety.
- Discussion of ongoing phase I/II trials.
Main Results:
- Immunomodulatory drugs (thalidomide, lenalidomide) and bortezomib are effective alone and in combination.
- These agents improve outcomes when integrated into transplant-based protocols.
- Ongoing research explores drug sequencing, synergy, and novel agents like arsenic trioxide.
Conclusions:
- Thalidomide, lenalidomide, and bortezomib are now standard first-line and later-line treatments for myeloma.
- Combinations of these drugs are valid choices for all disease stages.
- Future myeloma treatment will likely involve personalized plans based on genetic profiling.
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