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Related Concept Videos

The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
Accessory Structures of the Eye01:17

Accessory Structures of the Eye

Optical perception, or vision, is an extraordinary sense dependent on converting light signals received via the ocular organs. These organs, known as eyes, are securely positioned within the bony cavities of the skull, called orbits. The orbits serve a dual purpose: a protective shield for the ocular globes and a stable attachment point for the soft ocular tissues. The eye's external protective mechanisms include the eyelids, which are edged with lashes that act as a barrier against foreign...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
Muscles for Facial Expressions01:14

Muscles for Facial Expressions

The craniofacial muscles are a collection of approximately 20 thin skeletal muscles situated beneath the skin of the face and scalp. These muscles, primarily responsible for the vast array of human facial expressions, originate from the bones or fibrous structures of the skull and extend outwards to connect with the skin. While most skeletal muscles in the body are enveloped in thick fascia, facial muscles generally have a more delicate fascial covering, with the buccinator muscle being a...
Assessment of Airway, Skin Color, and Use of Accessory Muscles01:30

Assessment of Airway, Skin Color, and Use of Accessory Muscles

A thorough assessment of respiratory health is paramount in clinical settings to identify and manage respiratory distress and ensure adequate oxygenation. This article elaborates on the critical aspects of respiratory evaluation, including airway assessment, skin color examination, and the observation of accessory muscle use, which are integral to effectively diagnosing and managing patients with respiratory conditions.
Introduction
The initial evaluation of a patient's respiratory system...

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Related Experiment Video

Updated: Jul 11, 2026

Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration
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Observations on periorbital and midface aging.

Val Lambros1

  • 1Newport Beach, Calif. From the Department of Plastic Surgery, University of California, Irvine.

Plastic and Reconstructive Surgery
|September 28, 2007
PubMed
Summary

Facial aging reveals stable periorbital and midface features over decades. Upper eyelid shape changes, but vertical descent is not a primary aging factor in these areas.

Area of Science:

  • Aesthetic medicine
  • Plastic surgery
  • Dermatology

Background:

  • Facial aging mechanisms, particularly periorbital and midface changes, remain incompletely understood.
  • This study investigates the aging process linearly over time in these specific facial regions.

Purpose of the Study:

  • To analyze anatomical changes in the periorbital area and upper midface over extended periods.
  • To challenge common assumptions about vertical descent as the primary driver of facial aging in these zones.

Main Methods:

  • Comparison of historical photographs (10-50 years prior) with recent images of the same individuals.
  • Digital superimposition and GIF animation of matched old and new photographs to visualize temporal changes.

Main Results:

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Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration
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  • The lid-cheek junction shows remarkable positional stability, becoming more visible due to contrast rather than descent.
  • Orbicularis wrinkles, moles, and other midface markers remain stable over decades.
  • A characteristic change in upper eyelid shape occurs with aging, with the peak shifting centrally from a medial bias.

Conclusions:

  • Minimal ptosis (inferior descent) observed in the lid-cheek junction and upper midface suggests vertical descent is not a major aging component.
  • Characteristic alterations in upper eyelid shape are noted in some individuals.
  • The study visualizes known periorbital aging changes, emphasizing stability over descent.