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Related Experiment Videos

Lung function following first-trimester amniocentesis or chorion villus sampling.

P J Thompson1, A Greenough, K H Nicolaides

  • 1Department of Child Health, King's College Hospital Medical School, London, UK.

Fetal Diagnosis and Therapy
|January 1, 1991
PubMed
Summary

This study found no significant difference in infant lung function, measured by functional residual capacity (FRC), between mothers who underwent amniocentesis or chorionic villus sampling (CVS) during pregnancy. Both procedures appear safe for antenatal lung development.

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Area of Science:

  • Neonatal physiology
  • Prenatal diagnostics

Background:

  • First-trimester prenatal diagnostic procedures like amniocentesis and chorionic villus sampling (CVS) are crucial for genetic screening.
  • Potential effects of these invasive procedures on fetal development, particularly lung growth, require careful evaluation.

Purpose of the Study:

  • To compare the impact of amniocentesis versus CVS on functional residual capacity (FRC) in infants.
  • To assess the safety of these procedures regarding antenatal lung development.

Main Methods:

  • A randomized trial involving 100 infants whose mothers underwent either amniocentesis or CVS between 10-13 weeks gestation.
  • Functional residual capacity (FRC) was measured in infants at 2-8 weeks of age.
  • Statistical analysis compared FRC means between the two groups, with calculation of 95% confidence intervals.

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Main Results:

  • No statistically significant difference was observed in the mean FRC between infants exposed to amniocentesis (29.7 ml/kg) and CVS (30.4 ml/kg).
  • The 95% confidence interval for the difference in means ranged from -1.17 to 2.52 ml/kg, indicating no substantial divergence.
  • A small number of infants in both groups had FRC below the 2.5th centile, with no significant difference between groups.

Conclusions:

  • Amniocentesis and CVS are comparable in their effects on antenatal lung growth.
  • These first-trimester diagnostic procedures do not appear to adversely impact infant lung development as measured by FRC.