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Updated: Jul 11, 2026

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila
Published on: August 20, 2019
A novel ovary-specific and ovulation-associated variant of epoxide hydrolase 2
Ketty Shkolnik1, Shifra Ben-Dor, Dalia Galiani
1Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel.
Abstract:
Ovulation is a complex process initiated by the surge of the pituitary luteinizing hormone (LH) that provokes the expression of specific genes. We report herein the isolation and characterization of an ovulation-associated, ovary-specific novel isoform of epoxide hydrolase 2 (Ephx2), Ephx2C. This variant is exclusively expressed in the granulosa cells of preovulatory mouse ovarian follicles. The LH-induced expression of Ephx2C is mediated by the protein kinase A and partially by the protein kinase C signaling pathways. The involvement of p38 kinase has also been demonstrated.
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