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Disseminated nodular granulomatous perifolliculitis
S Das1, R Saha, S N Bhattacharya
1Department of Microbiology, University College of Medical Sciences and Guru Tegh Bahadur Hospital, New Delhi - 110 095, India. shukladas_123@yahoo.com
Indian Journal of Medical Microbiology
|September 29, 2007
Summary
Nodular granulomatous perifolliculitis, a deep fungal infection, can occur in immunosuppressed individuals. This case highlights Trichophyton rubrum causing extensive lesions, successfully treated with antifungal therapy.
Area of Science:
- Dermatology
- Mycology
Background:
- Nodular granulomatous perifolliculitis is a deep fungal infection typically caused by dermatophytes invading beyond the epidermis.
- Dermatophyte infections usually remain superficial, confined to the epidermis.
Observation:
- A 35-year-old farmer presented with a pruritic eruption that spread from the lower leg to hair-bearing areas.
- The eruption evolved into nodular and pustular inflammatory lesions with a relapsing-remitting course.
- The patient was immunosuppressed, a key factor in the atypical presentation.
Findings:
- Fungal examination confirmed Trichophyton rubrum as the causative agent.
- Histopathology revealed significant granulomatous changes in the affected tissues.
- The patient showed a complete response to systemic antifungal treatment.
Implications:
- This case underscores the potential for dermatophytes to cause deep-seated infections in immunosuppressed hosts.
- It highlights the importance of considering deep fungal infections in atypical presentations of skin lesions.
- Successful treatment with systemic antifungals demonstrates therapeutic efficacy for this rare condition.
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