Beta adrenergic receptors in keratinocytes
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Updated: Jul 11, 2026

Measuring the Rate of Lipolysis in Ex Vivo Murine Adipose Tissue and Primary Preadipocytes Differentiated In Vitro
Published on: March 17, 2023
Raja K Sivamani1, Susanne T Lam, R Rivkah Isseroff
1Department of Dermatology, University of California, Davis, School of Medicine, Dermatology Research, TB 192, One Shields Avenue, Davis, CA 95616, USA.
Abstract:
Beta2 adrenergic receptors were identified in keratinocytes more than 30 years ago, but their function in the epidermis continues to be elucidated. Abnormalities in their expression, signaling pathway, or in the generation of endogenous catecholamine agonists by keratinocytes have been implicated in the pathogenesis of cutaneous diseases such as atopic dermatitis, vitiligo, and psoriasis. New studies also indicate that the beta2AR also modulates keratinocyte migration, and thus can function to regulate wound reepithelialization. This review focuses on the function of these receptors in keratinocytes and their contribution to cutaneous physiology and disease.
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