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Published on: July 14, 2023
Poststroke epilepsy in the Copenhagen stroke study: incidence and predictors
Lars Peter Kammersgaard1, Tom Skyhøj Olsen
1Stroke Unit, Hvidovre University Hospital, Hvidovre, Denmark.
Summary
Poststroke epilepsy (PSE) affects about 3% of stroke survivors within seven years. Key predictors include younger age, stroke severity, larger lesion size, intracerebral hemorrhage, and early seizures.
Area of Science:
- Neurology
- Epileptology
- Stroke Medicine
Background:
- Poststroke epilepsy (PSE) is a significant complication following stroke.
- Existing data on PSE incidence and predictors in unselected populations is limited.
Purpose of the Study:
- To determine the incidence of PSE in a large, unselected stroke cohort.
- To identify independent predictors of PSE over a 7-year follow-up period.
Main Methods:
- A community-based prospective study of 1197 stroke patients.
- Follow-up for 7 years to identify recurrent epileptic seizures after stroke.
- Univariate and multiple logistic regression analyses to identify predictors.
Main Results:
- Overall incidence of PSE was 3.2% (38 patients) within 7 years.
- Independent predictors identified: younger age, greater stroke severity, larger lesion size, intracerebral hemorrhage, and early seizures.
- Younger age (OR 1.7/10 years), stroke severity (OR 1.3/10-point decrease), lesion size (OR 1.2/10-mm enlargement), intracerebral hemorrhage (OR 3.3), and early seizures (OR 4.5) were significant.
Conclusions:
- PSE incidence is approximately 3% within 7 years post-stroke.
- Identifying high-risk individuals (younger age, severe stroke, large lesions, hemorrhage, early seizures) is crucial for targeted prevention and management.
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