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Updated: Jul 11, 2026
Minimally Invasive Thumb-sized Pterional Craniotomy for Surgical Clip Ligation of Unruptured Anterior Circulation Aneurysms
Published on: August 11, 2015
Treatment with tissue plasminogen activator is not associated with increased use of neurosurgery
Enrique C Leira1, Salvador Cruz-Flores, Aninda B Acharya
1Souers Stroke Institute, Department of Neurology, Saint Louis University, St Louis, Missouri, USA.
Background:
Current guidelines of stroke care imply that tissue plasminogen activator (rtPA) should be only used in centers with a neurosurgeon available to manage any intracranial hemorrhage (ICH). Such advice may be difficult to follow with the current US shortage of neurosurgeons. It could also contribute to the underutilization of rtPA in smaller hospitals and might not be justified if, in practice, most ICHs were managed medically.
Methods:
Using the Health Cost Utilization Project 2000 sample we studied the relationship among ischemic stroke, ICH, and rtPA.
Results:
In this sample of 7,450,992 hospital admissions, 1516 patients had both ischemic stroke and ICH. Among these patients, 58 had received rtPA and 5 of those (8.6%) had a neurosurgical intervention. In the remaining 1458 patients who did not receive rtPA, 178 (12.2%) had neurosurgery. Therefore, the odds ratio for having a neurosurgical intervention for ICH after rtPA was 0.68 (95% confidence interval: 0.27-1.7).
Conclusions:
In this large sample of US hospital admissions as a result of acute ischemic stroke with overlapping hemorrhage, the use of rtPA was not associated with an increased number of neurosurgical interventions. This lack of association, which needs to be confirmed in prospective studies, argues against withholding treatment with rtPA in patients with stroke based on neurosurgical availability.
