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Updated: Jul 11, 2026

Visualizing Impairment of the Endothelial and Glial Barriers of the Neurovascular Unit during Experimental Autoimmune Encephalomyelitis In Vivo
Published on: March 26, 2019
Multifocal hemorrhagic vasculopathy: possibly a manifestation of central nervous system vasculitis
Olga Noskin1, Richard Libman, Stephan Mayer
1Department of Neurology, Long Island Jewish Medical Center, New Hyde Park, New York, USA.
Abstract:
We report a patient with multiple spontaneous intracerebral hemorrhages involving cortical, subcortical, and deep brain structures. Despite extensive evaluation, no etiology was identified, and the possibility of primary central nervous system (CNS) vasculitis was entertained. Brain biopsy revealed small vessels with a lymphocytic infiltrate in brain tissue adjacent to hemorrhage. Despite this nonspecific finding, the patient appeared to respond to immunosuppressive therapy. In this report we review the various presentations of CNS vasculitis and suggest that this diagnosis be considered in the setting of multiple spontaneous intracerebral hemorrhages.
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