Utilizing multibubble sonophotoluminscence for calcium quantitative analysis in pharmaceuticals

Sonoluminescence can photoexcite fluorescent solutes yielding sonophotoluminescence (SPL). The possibility of applying multibubble sonophotoluminescence (MBSPL) for chemical quantitative analysis is examined in this work. Special devices for MBSPL quantitative detection are designed and fabricated. Calcium contents in pharmaceutical samples are selected to verify the proposed MBSPL analysis. Coupled with flow fluid manifold, high detection frequency, good reproducibility and automatic operation are obtained. Further applications of presented method to detecting a variety of chemical or biochemical molecules in low quantities are expected.