Pyrazolo[1,5-a]pyrimidines as orally available inhibitors of cyclin-dependent kinase 2
Kamil Paruch1, Michael P Dwyer, Carmen Alvarez
1Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA. kamil.paruch@spcorp.com
Bioorganic & Medicinal Chemistry Letters
|October 2, 2007
Abstract:
Properly substituted pyrazolo[1,5-a]pyrimidines are potent and selective CDK2 inhibitors. Compound 15j is orally available and showed efficacy in a mouse A2780 xenograft model.
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