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Updated: Jul 11, 2026
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Vascularized Composite Hand Allograft Procurement and Preparation for Distal and Proximal Forearm Allotransplantation: A Stepwise Approach
Published on: May 23, 2025
[Hand allografts: experience from Lyon team].
A Gazarian1, D-O Abrahamyan, P Petruzzo
1Chirurgie de la main et du membre supérieur, clinique du Parc, 155, boulevard Stalingrad, 69006 Lyon, France. a.gazarian@cliniqueduparclyon.com
Annales De Chirurgie Plastique Et Esthetique
|October 2, 2007
Summary
Hand allografting, a clinical trial for traumatic amputees, shows promising sensorimotor recovery and social adaptation. Despite manageable complications, this composite tissue allotransplantation offers better outcomes than prostheses.
Area of Science:
- Transplantation immunology
- Reconstructive surgery
- Clinical experimentation
Context:
- Hand allografting is an experimental treatment for bilateral traumatic amputees in France.
- Pioneering experience from the Lyon team is detailed, involving seven hand transplantations between 1998 and 2007.
- The study focuses on patients with amputations at the wrist or mid-forearm, with a significant delay since hand loss.
Purpose:
- To report the Lyon team's experience with hand allografting in traumatic amputees.
- To evaluate the clinical, analytical, and functional outcomes of hand transplantation.
- To assess the safety and efficacy of immunosuppressive protocols in composite tissue allotransplantation.
Summary:
- Four patients underwent seven hand transplantations, with bilateral cases showing favorable evolution and good to excellent sensorimotor recovery.
- Acute rejections were managed effectively with oral prednisone and topical immunosuppressants; no severe long-term complications were noted.
- Functional recovery in bilateral recipients surpassed outcomes from myoelectric prostheses, indicating the potential of hand allografting.
Impact:
- Hand allografting demonstrates potential as a viable treatment option for traumatic hand loss, offering superior functional restoration compared to current prosthetics.
- The study supports the advancement of composite tissue allotransplantation (CTA) research and clinical application.
- Encouraging results warrant further long-term research and global monitoring to establish authorization criteria and understand CTA mechanisms.
