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[Possible role of the FGF23-Klotho axis in bone mineralization]
1Kirin Pharma Co., Ltd., Discovery Research Laboratories, Nephrology.
Abstract:
FGF23 was identified as a causative factor for hypophosphatemic rickets/osteomalacia. The following studies have confirmed its essential role in phosphate and vitamin D metabolism in normal physiology. Recent studies revealed that Klotho, originally identified as an aging-associated molecule, is necessary for the specific action of FGF23. Much attention is now paid to the FGF23-Klotho axis as a novel regulatory system in the mineral metabolism, whereas local action of FGF23 in bone metabolism or bone mineralization remains unresolved.
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