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Related Concept Videos

Ribosome Profiling02:24

Ribosome Profiling

Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique helps...
DNA Microarrays02:34

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...

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Related Experiment Video

Updated: Jul 11, 2026

Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells
16:24

Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells

Published on: February 21, 2014

Gene expression profiling in breast cancer.

Shannon R Morris1, Lisa A Carey

  • 1GlaxoSmithKline, Research Triangle Park and Division of Hematology/Oncology, University of North Carolina, Chapel Hill, NC 27599-7305, USA.

Current Opinion in Oncology
|October 2, 2007
PubMed
Summary
This summary is machine-generated.

Gene expression profiling reveals breast cancer

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Last Updated: Jul 11, 2026

Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells
16:24

Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells

Published on: February 21, 2014

Area of Science:

  • Genomics
  • Oncology
  • Molecular Biology

Background:

  • Breast cancer exhibits significant biological heterogeneity.
  • Gene expression profiling is advancing personalized medicine in oncology.

Purpose of the Study:

  • Review recent advances in gene expression profiling for breast cancer.
  • Focus on applications relevant to practicing oncologists.

Main Methods:

  • Analysis of gene expression profiling technologies.
  • Review of clinical trial data for prognostic assays.
  • Examination of predictive profiling in development.

Main Results:

  • Two prognostic assays (Mammaprint, Oncotype Dx) are in Phase III trials.
  • Predictive profiles for chemotherapy and targeted therapy are emerging.
  • Profiling identifies key carcinogenic processes like proliferation.

Conclusions:

  • Genome-wide profiling clarifies breast cancer heterogeneity.
  • Prognostic profiles may guide intensive therapy decisions.
  • Predictive profiles and new therapeutic targets are advancing breast cancer treatment.