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Psoriasis of the face and flexures
Peter C M van de Kerkhof1, Gillian M Murphy, Joar Austad
1Department of Dermatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands. P.vandekerkhof@derma.umcn.nl
The Journal of Dermatological Treatment
|October 2, 2007
Summary
Facial and flexural psoriasis significantly impact quality of life. First-line treatments include topical corticosteroids, vitamin D3 analogues, and calcineurin inhibitors, with an individualized approach recommended for optimal patient outcomes.
Area of Science:
- Dermatology
- Immunology
Background:
- Facial and flexural psoriasis are common and significantly impact patient quality of life.
- These conditions require specific management strategies distinct from psoriasis on other body sites.
Purpose of the Study:
- To provide evidence-based recommendations for the management of facial and flexural psoriasis.
- To synthesize current knowledge on epidemiology, clinical presentation, pathogenesis, and treatment.
Main Methods:
- Extensive literature search on facial and flexural psoriasis.
- Expert panel discussion and consensus formulation by the Copenhagen Psoriasis Working Group (CPWG).
Main Results:
- Facial psoriasis affects 17-46% and flexural psoriasis 6.8-36% of patients; facial psoriasis indicates a poor prognosis.
- First-line treatments include low-potency topical corticosteroids, vitamin D3 analogues, and calcineurin inhibitors; antimicrobial treatments are not indicated.
- Phototherapy and systemic treatments are reserved for cases unresponsive to topical therapies.
Conclusions:
- An individualized treatment approach is crucial for facial and flexural psoriasis.
- Combination therapy with vitamin D3 analogues and low-strength corticosteroids is recommended for future drug development.
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