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Chronic Salmonella Infection Induced Intestinal Fibrosis
Published on: September 22, 2019
Infertility associated with sub clinical salmonellosis.
Bhoj Raj Singh1, Mudit Chandra, Ravikant Agarwal
1National Salmonella Centre (Vet.), Division of Bacteriology and Mycology, Indian Veterinary Research Institute, Izatnagar 243 122, India. brs1762@yahoo.co.in
Indian Journal of Experimental Biology
|October 3, 2007
Summary
Subclinical Salmonella Abortusequi infection in guinea pigs caused infertility. Wild-type Salmonella, not mutants, significantly reduced conception rates, proving its role in infertility.
Area of Science:
- Veterinary Microbiology
- Infectious Diseases
- Reproductive Biology
Background:
- Salmonella enterica subspecies enterica serovar Abortusequi (S. Abortusequi) is a known cause of abortion in livestock.
- The impact of S. Abortusequi infection on conception rates and infertility in guinea pigs remains underexplored.
- Understanding the virulence factors of S. Abortusequi is crucial for developing effective control strategies.
Purpose of the Study:
- To investigate the role of subclinical S. Abortusequi infection in guinea pig infertility.
- To compare the effects of wild-type S. Abortusequi and its isogenic mutants (aroA, htrA, aroA-htrA) on conception rates.
- To identify specific S. Abortusequi virulence factors associated with reduced fertility.
Main Methods:
- Guinea pigs were subclinically infected with wild-type S. Abortusequi and its isogenic mutants (aroA, htrA, aroA-htrA).
- Conception rates were monitored and compared between groups.
- Statistical analysis (Chi-test) was employed to determine the significance of infection and specific mutants on conception rates.
Main Results:
- Subclinical infection with wild-type S. Abortusequi and the aroA mutant significantly reduced conception rates in guinea pigs.
- Intracellular survival-deficient mutants (htrA and aroA-htrA) had minimal impact on conception rates.
- Wild-type Salmonella infection and chronic carriage were identified as significant causes of low conception rates.
Conclusions:
- This study provides the first experimental evidence for the role of S. Abortusequi in causing infertility in guinea pigs.
- Virulence factors associated with intracellular survival are critical for S. Abortusequi's impact on reproductive success.
- Targeting these virulence factors could be a potential strategy for mitigating S. Abortusequi-induced infertility.
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