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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

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Metaphylactic Antimicrobial Use and Antimicrobial Stewardship in Beef Stocker Cattle.

Brent Credille¹

¹Veterinary Technical Solutions (VeTS, Large Animal), Boehringer Ingelheim Animal Health, USA.

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|July 15, 2026

Summary

Bovine respiratory disease significantly impacts stocker cattle health and profitability. Macrolide antimicrobials show efficacy, but antimicrobial resistance and public perception pose challenges for their use in beef production.

Keywords:

Antimicrobial Antimicrobial resistance Antimicrobial stewardship Bovine respiratory disease Cattle Metaphylaxis

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Published on: March 23, 2014

Area of Science:

Veterinary Medicine
Animal Science
Agricultural Economics

Background:

Bovine respiratory disease (BRD) is a major cause of morbidity and mortality in stocker cattle.
BRD significantly affects animal welfare, performance, and farm profitability in the beef industry.
Antimicrobial metaphylaxis is a common strategy to control BRD.

Purpose of the Study:

To review the efficacy of macrolide antimicrobials for BRD metaphylaxis in stocker cattle.
To discuss the challenges posed by antimicrobial resistance and public perception regarding antimicrobial use in animal agriculture.

Main Methods:

Literature review of studies on BRD treatment and prevention in stocker cattle.
Analysis of antimicrobial efficacy data, focusing on the macrolide class.
Discussion of emerging antimicrobial resistance trends and public perception issues.

Main Results:

Macrolide antimicrobials have demonstrated the greatest efficacy among approved agents for BRD metaphylaxis.
Antimicrobial resistance is an increasing concern, potentially reducing the effectiveness of current treatments.
Negative public perception of antimicrobial use in food animal production presents a significant challenge.

Conclusions:

Macrolides remain a highly effective choice for BRD metaphylaxis in stocker cattle.
Addressing antimicrobial resistance and improving public perception are critical for sustainable antimicrobial use in beef production.
Continued research and responsible stewardship are necessary to maintain the efficacy of antimicrobials in the stocker industry.