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Updated: May 7, 2026
11:28
Analytical Techniques for Assaying Nitric Oxide Bioactivity
Published on: June 18, 2012
Clinical aspects of nitrate tolerance
1University of New Mexico School of Medicine, Department of Medicine, Albuquerque.
European Heart Journal
|November 1, 1991
Summary
Nitrate tolerance, a significant issue in cardiovascular medicine, can be managed with specific dosing strategies. Future research aims to develop new treatments to overcome this limitation and enhance the benefits of organic nitrates.
Area of Science:
- Cardiovascular Medicine
- Pharmacology
Background:
- Organic nitrates are essential cardiovascular drugs.
- Nitrate tolerance limits their therapeutic effectiveness.
- Understanding tolerance mechanisms is crucial for optimizing treatment.
Purpose of the Study:
- To review strategies for avoiding nitrate tolerance.
- To discuss emerging therapies like thiol donors and ACE inhibitors.
- To highlight the need for future research in this area.
Main Methods:
- Review of existing literature on nitrate tolerance.
- Analysis of dosing regimens and their impact on tolerance.
- Exploration of pharmacological interventions.
Main Results:
- Nitrate tolerance is often avoidable with proper dosing.
- Specific dosing regimens, including nitrate-free intervals, can prevent tolerance.
- Thiol donors and ACE inhibitors show potential but require further study.
Conclusions:
- Optimizing dosing is key to managing nitrate tolerance.
- Further research is needed to develop novel strategies.
- Overcoming nitrate tolerance will expand the clinical utility of these vital drugs.
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