Related Experiment Videos
A study on the chronopharmacokinetics of theophylline in rabbits
A Kumar1, A Chakrabarti, S K Garg
1Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh.
Indian Journal of Physiology and Pharmacology
|July 1, 1991
Abstract:
The Chronopharmacokinetics of a single oral dose of theophylline was studied in rabbits. It was observed that morning (06.00 hr) dosing was characterized by significantly low rate of absorption (t 1/2a and Tmax) but higher extent of absorption (AUC0-alpha) compared to that after nocturnal dosing (22.00 hr). The plasma half life (t1/2el) was significantly less at night compared to that in daytime. The data may have considerable clinical relevance.