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Related Concept Videos

Gene Therapy00:59

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be inserted. The...

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Related Experiment Video

Updated: Jul 11, 2026

Transient Expression of Proteins by Hydrodynamic Gene Delivery in Mice
12:54

Transient Expression of Proteins by Hydrodynamic Gene Delivery in Mice

Published on: May 5, 2014

Hydrodynamic gene delivery: its principles and applications.

Takeshi Suda1, Dexi Liu

  • 11Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, Pittsburgh, Pennsylvania 15261, USA.

Molecular Therapy : the Journal of the American Society of Gene Therapy
|October 4, 2007
PubMed
Summary
This summary is machine-generated.

Hydrodynamic gene delivery offers a simple, efficient, and versatile method for in vivo gene therapy. This review covers the theory and practice of this promising technique for preclinical and clinical applications.

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Area of Science:

  • Biotechnology
  • Molecular Biology
  • Gene Therapy

Background:

  • Clinical application of gene therapy requires efficient and safe genetic material delivery methods.
  • Hydrodynamic gene delivery, involving rapid injection of DNA solutions, has emerged as a promising in vivo approach.
  • Existing delivery systems have limitations, driving the need for advanced techniques.

Purpose of the Study:

  • To provide a comprehensive overview of hydrodynamic gene delivery.
  • To discuss the theory and practical aspects of this gene delivery method.
  • To assist researchers in utilizing hydrodynamic gene delivery for preclinical and translational studies.

Main Methods:

  • Review of existing literature on hydrodynamic gene delivery principles and applications.
  • Analysis of the advantages of hydrodynamic delivery over conventional methods.
  • Exploration of successful applications in various tissues of small animals.

Main Results:

  • Hydrodynamic gene delivery demonstrates simplicity, efficiency, and versatility.
  • Successful delivery of DNA, RNA, proteins, and synthetic compounds in vivo.
  • Growing interest in adapting hydrodynamic procedures for clinical use.

Conclusions:

  • Hydrodynamic gene delivery is a valuable tool for advancing gene therapy research.
  • Further development of this method is crucial for its clinical translation.
  • This review serves as a guide for researchers in preclinical and translational gene therapy studies.