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Updated: Jul 11, 2026

06:50
Computational Prediction of Amino Acid Preferences of Potentially Multispecific Peptide-Binding Domains Involved in Protein-Protein Interactions
Published on: January 26, 2024
Evaluation of a carbohydrate-pi interaction in a peptide model system
Sarah E Kiehna1, Zachary R Laughrey, Marcey L Waters
1Department of Chemistry, CB 3290, University of North Carolina, Chapel Hill, NC 27599, USA.
Abstract:
A carbohydrate-pi interaction contributes -0.8 kcal mol(-1) to the stabilization of a beta-hairpin peptide.
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A peptide bond covalently attaches amino acids through a dehydration reaction. One amino acid's carboxyl group and another amino acid's amino group combine, releasing a water molecule. The resulting bond is the peptide bond. The products that such linkages form are peptides. As more amino acids join this growing chain, the resulting chain is a polypeptide. Each polypeptide has a free amino group at one end. This end has the N-terminal, or the amino-terminal, and the other end has a free...

