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The quick-implantable-defibrillator trial.

Dietmar Bänsch1, Hans Kottkamp, Gerian Grönefeld

  • 1Department of Cardiology, St. Georg's Hospital, Hamburg, Germany. dietmarbaensch@alice-dsl.de

Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology
|October 5, 2007
PubMed
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Simplifying implantable cardioverter-defibrillator (ICD) implantation by omitting electrophysiological studies (EPS) and extensive defibrillation threshold tests (DFT) is safe and effective for patients who survived cardiac arrest or ventricular tachycardia. This approach reduces hospital stay without compromising patient outcomes.

Area of Science:

  • Cardiology
  • Medical Devices
  • Clinical Trials

Background:

  • Implantable cardioverter-defibrillator (ICD) implantation protocols have evolved, with many centers reducing or eliminating electrophysiological studies (EPS), extensive defibrillation threshold tests (DFT), and pre-discharge tests.
  • The safety and efficacy of these simplified ICD implantation strategies have not been prospectively demonstrated.

Purpose of the Study:

  • To prospectively evaluate the safety and effectiveness of a simplified ICD implantation strategy compared to an extensive strategy in patients who survived sudden cardiac arrest (SCA) or unstable ventricular tachycardia (VT).

Main Methods:

  • The Quick-Implantable-Defibrillator (Quick-ICD) Trial was a prospective, multi-center study randomizing 190 patients to either an extensive strategy (including EPS, extensive DFT, and pre-discharge test) or a quick strategy (ICD implantation without EPS and pre-discharge test, with two 21 J shocks).

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  • The primary endpoint was a composite of adverse events related to the diagnostic approach and ICD therapy.
  • Patients were followed for a mean of 12 months.
  • Main Results:

    • Event-free survival was equivalent between the quick strategy group (27 events) and the extensive strategy group (32 events) (P = 0.0044 for equivalence).
    • The initial hospital stay was significantly shorter in the quick strategy group (8.4 days) compared to the extensive strategy group (11.2 days) (P = 0.004).

    Conclusions:

    • A simplified ICD implantation protocol, omitting electrophysiological studies (EPS), extensive defibrillation threshold tests (DFT), and pre-discharge tests, is safe and cost-effective in carefully selected patients post-sudden cardiac arrest (SCA) or ventricular tachycardia (VT).
    • This streamlined approach leads to shorter hospitalizations without compromising patient safety or treatment efficacy.