Randomized controlled study of biocompatible peritoneal dialysis solutions: effect on residual renal function

Area of Science:

• Nephrology
• Renal Replacement Therapy

Background:

• Residual kidney function (RRF) is crucial for patient and technique survival in peritoneal dialysis (PD).
• Biocompatible dialysis solutions are hypothesized to enhance mesothelial cell function and preserve RRF.

Purpose of the Study:

• To compare the efficacy of biocompatible versus standard dialysis solutions in preserving RRF in incident PD patients over one year.

Main Methods:

• A randomized controlled study involving 93 incident PD patients.
• Comparison of biocompatible (B) and standard (S) solutions over a 12-month period.
• Assessment of 24-hour urine volume, urea, and creatinine clearance normalized to body surface area at 3 and 12 months.

Main Results:

• No significant differences were observed in the changes of normalized mean urea and creatinine clearance between the biocompatible and standard solution groups.
• Secondary endpoints, including fluid status markers, diuretic use, C-reactive protein, peritonitis episodes, and survival, showed no significant differences.
• Clinically significant advantages of biocompatible solutions were not detected within the study duration.

Conclusions:

• The study did not find significant short-term benefits of biocompatible dialysis solutions in preserving residual renal function in PD patients compared to standard solutions.
• Further long-term studies are warranted to explore potential benefits of biocompatible solutions in peritoneal dialysis.