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4-Dimensional Imaging of Zebrafish Optic Cup Morphogenesis
Published on: May 26, 2021
Developmental abnormalities of the optic nerve and chiasm
1Institute of Child Health, Visual Sciences Unit, London, UK. d.taylor@ich.ucl.ac.uk
Eye (London, England)
|October 5, 2007
Summary
Developmental optic nerve anomalies cause lifelong visual impairment and are linked to systemic issues. This review details ocular and systemic aspects of these birth defects.
Area of Science:
- Ophthalmology
- Developmental Biology
- Genetics
Background:
- Developmental anomalies of the optic nerve represent a significant and increasing cause of permanent visual handicap.
- These conditions are frequently associated with broader systemic abnormalities, highlighting a complex interplay between ocular and systemic development.
- Understanding these anomalies is crucial for early diagnosis and management to mitigate lifelong visual impairment.
Purpose of the Study:
- To review the ocular and systemic aspects of developmental anomalies of the optic nerve.
- To focus on anomalies arising from defects in fetal fissure closure and retinal ganglion cell development.
- To discuss other optic disc anomalies with significant systemic implications.
Main Methods:
- Literature review of developmental anomalies of the optic nerve.
- Synthesis of information on ocular manifestations.
- Analysis of associated systemic abnormalities.
Main Results:
- Optic nerve developmental anomalies are a growing cause of visual handicap.
- Defects in fetal fissure closure and retinal ganglion cell development are key etiological factors.
- Several optic disc anomalies carry significant systemic associations.
Conclusions:
- Developmental optic nerve anomalies require comprehensive evaluation, considering both ocular and systemic factors.
- Early identification and management are essential to address visual handicap and associated systemic conditions.
- Further research into the genetic and developmental pathways is warranted.
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